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Even a 2°C drop in the core body temperature can cause hypothermia. At this point, the effects of cold on the brain are most apparent. "At 18°C, we'll have a massive leak in our blood-brain barrier, and the brain is not protected anymore from the normal junk we produce," Gracheva said. The resulting flood of toxins through the hole-ridden ... Sign up for ScienceAdviser. Subscribe to ScienceAdviser to get the latest news, commentary, and research, free to your inbox daily. My Account | Science | AAAS We offer options for both institutions and individuals to access Science content. Institutions. If you are a librarian, please use our form to request a quote or a trial subscription for any of our journals. Institutions can subscribe to receive the weekly print edition of Science either directly or through LOGIN and enjoy all the benefits of being a member of AAAS! Why Join. 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